产品货号：
Z31001
中文名称：
Cyclin D1/CCND1抗体
英文名称：
Anti-Cyclin D1/CCND1 Antibody (Clone#1849CT557.93.5)
产品规格：
50μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-Cyclin D1/CCND1 Antibody (Clone#1849CT557.93.5) |
| 指标别名 | B cell lymphoma 1 protein;CCND1;cyclin D;Cyclin D1;D11S287E;G1/S specific cyclin D1;PRAD1;PRAD1 oncogene;U21B31 |
| 克隆性 | Monoclonal |
| 检验物种 | human,mouse |
| 应用范围 | WB |
| 基因名称 | CCND1 |
| 克隆号 | 1849CT557.93.5 |
| 抗体来源 | Mouse |
| 免疫原 | This antibody is generated from a mouse immunized with a recombinant protein from human. |
| 计算分子量 | 34kDa |
| 成分 | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. |
| 纯化方式 | This antibody is purified through a protein G column,followed by dialysis against PBS |
| 保存条件 | Maintain refrigerated at 2～8℃ for up to 2 weeks.For long term storage,store at -20℃ in small aliquots to prevent freeze-thaw cycles. |
| 背景资料 | Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G (1)/S transition.Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G (1) phase.Hypophosphorylates RB1 in early G (1) phase.Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals.Also substrate for SMAD3,phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity.Component of the ternary complex,cyclin D1/CDK4/CDKN1B,required for nuclear translocation and activity of the cyclin D-CDK4 complex.Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner. |
| Uniprot ID | P24385 |
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